SBE 13 hydrochloride
- Product Name
- SBE 13 hydrochloride
- CAS No.
- 1052532-15-6
- Chemical Name
- SBE 13 hydrochloride
- Synonyms
- CS-1632;SBE-13 HCl;SBE13 HydrochL;SBE 13 hydrochloride;SBE 13 hydrochloride USP/EP/BP;SBE 13 hydrochloride >=98% (HPLC);N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine;N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine;N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride;N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
- CBNumber
- CB82552606
- Molecular Formula
- C24H28Cl2N2O4
- Formula Weight
- 479.4
- MOL File
- 1052532-15-6.mol
SBE 13 hydrochloride Property
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: ≥17mg/mL
- form
- powder
- color
- white to tan
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0012
- Product name
- SBE 13 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2022/05/15
- Product number
- 21241
- Product name
- SBE 13 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 21241
- Product name
- SBE 13 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 21241
- Product name
- SBE 13 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $232
- Updated
- 2024/03/01
- Product number
- 21241
- Product name
- SBE 13 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $421
- Updated
- 2024/03/01
SBE 13 hydrochloride Chemical Properties,Usage,Production
Description
SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC50 = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC50 > 66 μM) and Plk3 (IC50 = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC50 = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.
Uses
SBE13 Hydrochloride is a selective inhibitor of PLK1.
in vitro
to determine its ability to induce cell death in cancer cells, we applied kinase assays, western blot analyses, facs can analyses, caspase assays and immunofluorescence studies. we detected decreased cell proliferation, delayed progression through the cell cycle in lower sbe13 concentrations, a g2/m arrest using higher sbe13 concentrations followed by apoptosis, and abnormal mitotic figures. notably, sbe13 did not influence activity of other kinases (plk2, plk3, aurora a), indicating the selectivity of this type ii plk1 inhibitor [1].
SBE 13 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
SBE 13 hydrochloride Suppliers
View Lastest Price from SBE 13 hydrochloride manufacturers
- Product
- N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine,hydrochloride 1052532-15-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23